Iptacopan (hydrochloride) [CAS 1646321-63-2]
Iptacopan (hydrochloride) [CAS 1646321-63-2]
SKU:QM-0142156-01
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Product Details
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Description
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [1][2][3].
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CAS Number
[1646321-63-2]
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Molecular Formula
C25H31ClN2O4
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Molecular Weight
458.98
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Smiles
O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl
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Target
Complement System
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Purity
99.88
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Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319
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Precautions
H315, H319
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Iptacopan (hydrochloride) [CAS 1646321-63-2]
Iptacopan (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.