Iptacopan (hydrochloride hydrate) [CAS 2447007-60-3]
Iptacopan (hydrochloride hydrate) [CAS 2447007-60-3]
SKU:QM-0016765
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Product Details
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Description
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [1][2][3].
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CAS Number
[2447007-60-3]
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Molecular Formula
C25H33ClN2O5
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Molecular Weight
476.99
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Smiles
CC(C=C1OC)=C(NC=C2)C2=C1CN3[C@H](C4=CC=C(C=C4)C(O)=O)C[C@H](CC3)OCC.Cl.O
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Target
Complement System
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Shipping Conditions
Room temperature
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Iptacopan (hydrochloride hydrate) [CAS 2447007-60-3]
Iptacopan (hydrochloride hydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.