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Itacnosertib (hydrochloride) [CAS 2409543-84-4]
Itacnosertib (hydrochloride) [CAS 2409543-84-4]
SKU:QM-0136473-01
£376.83 GBP
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Product Details
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Description
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM) . Itacnosertib hydrochloride exhibits anti-leukemic activity[1][2].
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CAS Number
[2409543-84-4]
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Molecular Formula
C26H29ClN8O
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Molecular Weight
505.01
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Smiles
CN1CCN(C2=CC=C(NC3=NC=CC(NC4=CC=CN=C4C5=NC=CC=C5)=N3)C=C2OC)CC1.[H]Cl
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Target
Akt; Anaplastic lymphoma kinase (ALK) ; FLT3; JAK; mTOR; PI3K; STAT; TGF-beta/Smad; TGF-β Receptor
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Isoform
ALK2; JAK2
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Concentration
10mM
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Purity
99.43
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Solubility
DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Itacnosertib (hydrochloride) [CAS 2409543-84-4]
Itacnosertib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.