Ivaltinostat [CAS 936221-33-9]
Ivaltinostat [CAS 936221-33-9]
SKU:QM-0073405
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Product Details
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Description
Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects[1][2][3][4].
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CAS Number
[936221-33-9]
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Molecular Formula
C24H33N3O4
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Molecular Weight
427.54
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Smiles
O=C(NCCCN(C)C)/C(COC1=C2C=CC=CC2=CC=C1)=C/CCCCC(NO)=O
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Target
Apoptosis; HDAC; MDM-2/p53
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Isoform
HDAC
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Ivaltinostat [CAS 936221-33-9]
Ivaltinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.