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JAK-2/3-IN-3 [CAS 2242031-31-6]
JAK-2/3-IN-3 [CAS 2242031-31-6]
SKU:QM-0069296
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Product Details
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Description
JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia[1].
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CAS Number
[2242031-31-6]
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Molecular Formula
C13H10Cl2N4O2
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Molecular Weight
325.15
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Smiles
O=C1NC2=C(N=C1C3=C(N(C)N=C3C)O)C=C(Cl)C(Cl)=C2
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Target
Apoptosis; JAK
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Isoform
JAK2; JAK3
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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JAK-2/3-IN-3 [CAS 2242031-31-6]
JAK-2/3-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.