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JAK-IN-40
JAK-IN-40
SKU:QM-0009712
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Product Details
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Description
JAK-IN-40 (Compound 46) is the inhibitor for JAK that inhibits JAK1, JAK2 and JAK3 with IC50s of 0.022, 0.759 and 1.601 μM, respectively. JAK-IN-40 inhibits the phosphorylation of STAT3. JAK-IN-40 inhibits the proliferation of cancer cell Ba/F3 and JAK1-TEL Ba/F3 with GI50 of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle of H1975 and H2087 at G2/M phase, induces apoptosis. JAK-IN-40 exhibits a synergistic antitumor effect with Osimertinib.
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Molecular Formula
C26H32N8O3S
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Molecular Weight
536.65
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Smiles
O=C(NC1=CC=CC(C2=CSC3=CN=C(NC4=CN(C)N=C4OC)N=C32)=C1)[C@@H](C)N5CCN(CCO)CC5
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Target
Apoptosis; JAK; STAT
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Shipping Conditions
Room temperature
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JAK-IN-40
JAK-IN-40 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.