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JAK2-IN-13
JAK2-IN-13
SKU:QM-0012736
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Product Details
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Description
JAK2-IN-13 is a potent and orally active JAK2 inhibitor with an IC50 of 54.7 nM. JAK2-IN-13 downregulates the expressions of p-STAT3 and p-STAT5. JAK2-IN-13 exhibits good bioavailability and potent inhibition of rhEPO-induced extramedullary erythropoiesis and polycythemia vera. JAK2-IN-13 can be used for the study of myeloproliferative neoplasms[1].
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Molecular Formula
C25H28ClN5O2
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Molecular Weight
465.98
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Smiles
CC1=CN=C(NC(C=C2)=CC3=C2OCCN4CCCC4)N=C1NC5=CC(Cl)=CC(COC3)=C5
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Target
JAK; STAT
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Isoform
JAK2; STAT3; STAT5
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Shipping Conditions
Room temperature
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JAK2-IN-13
JAK2-IN-13 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.