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JAK2-IN-14 [CAS 3087335-24-5]
JAK2-IN-14 [CAS 3087335-24-5]
SKU:QM-0013348
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Product Details
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Description
JAK2-IN-14 is an orally active JAK2 inhibitor with an IC50 of 2 nM. JAK2-IN-14 demonstrates 89.5-, 80.5-, and 51-fold selectivity over JAK1, JAK3, and TYK2, respectively. JAK2-IN-14 inhibits STAT5 signaling pathway. JAK2-IN-14 causes tumor cell cycle arrest and apoptosis. JAK2-IN-14 can used for the study of myeloproliferative neoplasms (MPNs) [1].
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CAS Number
[3087335-24-5]
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Molecular Formula
C26H33N7O
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Molecular Weight
459.59
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Smiles
CC1=CN=C(NC2=CC=C(N3CCN(CC4CC4)CC3)C5=C2)N=C1C6=CN(CCCCO5)N=C6
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Target
Apoptosis; JAK; STAT
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Isoform
JAK1; JAK2; JAK3; STAT5; Tyk2
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Shipping Conditions
Room temperature
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JAK2-IN-14 [CAS 3087335-24-5]
JAK2-IN-14 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.