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JAK2-IN-15 [CAS 3094174-82-7]
JAK2-IN-15 [CAS 3094174-82-7]
SKU:QM-0015582
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Product Details
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Description
JAK2-IN-15 is an orally active, potent, selective JAK2 inhibitor (IC50 = 1.17 nM). JAK2-IN-15 can inhibit the AK2-STAT signaling pathway. JAK2-IN-15 significantly improves key pathological indicators such as hematocrit and splenomegaly in an Epoetin beta (rhEPO) -induced mouse model. JAK2-IN-15 can be used for the study of Polycythemia Vera (PV).
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CAS Number
[3094174-82-7]
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Molecular Formula
C29H35N5O4
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Molecular Weight
517.62
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Smiles
CC1=C2N=C(NC3=CC=C(C(COC/C=C/COCC4=CC=CC(N2)=C4)=C3)OCCN5CCOCC5)N=C1
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Target
JAK; STAT
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Isoform
JAK2
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Shipping Conditions
Room temperature
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JAK2-IN-15 [CAS 3094174-82-7]
JAK2-IN-15 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.