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JNJ-39758979 (dihydrochloride)
JNJ-39758979 (dihydrochloride)
SKU:QM-0057044
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Product Details
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Description
JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H4 receptor antagonist, with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride shows good anti-inflammatory and antipruritic activity[1][2].
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Molecular Formula
C11H21Cl2N5
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Molecular Weight
294.22
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Smiles
NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1.[H]Cl.[H]Cl
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Target
Histamine Receptor
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Isoform
H4 Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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JNJ-39758979 (dihydrochloride)
JNJ-39758979 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.