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KDOAM-25 (trihydrochloride)
KDOAM-25 (trihydrochloride)
SKU:QM-0057194
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Product Details
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Description
KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
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Molecular Formula
C15H28Cl3N5O2
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Molecular Weight
416.77
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Smiles
NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.Cl.Cl.Cl
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Target
Histone Demethylase
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Isoform
KDM5
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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KDOAM-25 (trihydrochloride)
KDOAM-25 (trihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.