KW-2478 (hydrochloride) [CAS 819812-18-5]
KW-2478 (hydrochloride) [CAS 819812-18-5]
SKU:QM-0006123
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Product Details
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Description
KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM) . KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer[1][2].
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CAS Number
[819812-18-5]
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Molecular Formula
C30H43ClN2O9
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Molecular Weight
611.12
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Smiles
O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC.Cl
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Target
Apoptosis; Bcr-Abl; CDK; HSP; p38 MAPK; STAT
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Shipping Conditions
Room temperature
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KW-2478 (hydrochloride) [CAS 819812-18-5]
KW-2478 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.