L-733060 (hydrochloride) [CAS 148687-76-7]
L-733060 (hydrochloride) [CAS 148687-76-7]
SKU:QM-0065641
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Product Details
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Description
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 hydrochloride mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 hydrochloride blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 hydrochloride reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 hydrochloride can be used for the study of chronic orofacial pain[1][2][3].
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CAS Number
[148687-76-7]
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Molecular Formula
C20H20ClF6NO
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Molecular Weight
439.82
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Smiles
FC(F)(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@@](C3=CC=CC=C3)([H])NCCC2)=C1)F.Cl
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Target
Neurokinin Receptor
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Isoform
NK1R
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Purity
99.9
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Solubility
H2O : 22 mg/mL (warming)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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L-733060 (hydrochloride) [CAS 148687-76-7]
L-733060 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.