Landiolol (hydrochloride) [CAS 144481-98-1]
Landiolol (hydrochloride) [CAS 144481-98-1]
SKU:QM-0079504-01
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Product Details
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Description
Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury[1][2][3].
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CAS Number
[144481-98-1]
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Molecular Formula
C25H40ClN3O8
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Molecular Weight
546.05
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Smiles
O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2.[H]Cl
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Target
Adrenergic Receptor; Calcium Channel; Potassium Channel; Reactive Oxygen Species (ROS)
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Isoform
Inwardly rectifying potassium channel; L-type calcium channel; β adrenergic receptor
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Purity
99.96
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Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319
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Precautions
H315, H319
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Landiolol (hydrochloride) [CAS 144481-98-1]
Landiolol (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.