Lenalidomide-13C5,15N
Lenalidomide-13C5,15N
SKU:QM-0087735
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Product Details
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Description
Lenalidomide-13C5,15N is 15N and 13C labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
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Molecular Formula
C8 13C5H13N2 15NO3
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Molecular Weight
265.22
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Smiles
O=C1C2=CC=CC(N)=C2C[15N]1[13CH]([13C](N3)=O)[13CH2][13CH2][13C]3=O
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Target
Apoptosis; Isotope-Labeled Compounds; Ligands for E3 Ligase; Molecular Glues
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Isoform
Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Lenalidomide-13C5,15N
Lenalidomide-13C5,15N is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.