Lenalidomide-C4-NH2 (hydrochloride) [CAS 2435715-90-3]
Lenalidomide-C4-NH2 (hydrochloride) [CAS 2435715-90-3]
SKU:QM-0138631-01
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Product Details
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Description
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
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CAS Number
[2435715-90-3]
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Molecular Formula
C17H22ClN3O3
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Molecular Weight
351.83
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Smiles
O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
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Target
E3 Ligase Ligand-Linker Conjugates
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Isoform
Cereblon
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Purity
98.85
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Solubility
DMSO : 130 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Lenalidomide-C4-NH2 (hydrochloride) [CAS 2435715-90-3]
Lenalidomide-C4-NH2 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.