Lenalidomide (hydrochloride) [CAS 1243329-97-6]
Lenalidomide (hydrochloride) [CAS 1243329-97-6]
SKU:QM-0000756
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Product Details
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Description
Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
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CAS Number
[1243329-97-6]
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Molecular Formula
C13H14ClN3O3
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Molecular Weight
295.72
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Smiles
O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O.[H]Cl
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Target
Ligands for E3 Ligase; Molecular Glues
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Isoform
Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H360-H373
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Precautions
P260-P280-P405-P501
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Lenalidomide (hydrochloride) [CAS 1243329-97-6]
Lenalidomide (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.