Leukotriene A4 methyl ester [CAS 73466-12-3]
Leukotriene A4 methyl ester [CAS 73466-12-3]
SKU:QM-0137599-01
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Product Details
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Description
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
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CAS Number
[73466-12-3]
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Molecular Formula
C21H32O3
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Molecular Weight
332.48
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Smiles
O=C(OC)CCC[C@@H]1O[C@H]1/C=C/C=C/C=C\C/C=C\CCCCC
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Target
Biochemical Assay Reagents
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Shipping Conditions
Room temperature
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Hazard Statement
H225-H304-H315-H319-H336-H361-H373-H411
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Precautions
P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P273-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P331-P362+P364-P370+P378-P391-P403+P233-P403+P235-P405-P501
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Leukotriene A4 methyl ester [CAS 73466-12-3]
Leukotriene A4 methyl ester is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.