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Leuxinostat
Leuxinostat
SKU:QM-0088190
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Product Details
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Description
Leuxinostat is an inhibitor for HDAC with IC50 of 30 nM for hHDAC6. Leuxinostat inhibits the proliferation of cells THP1, K562, U937 and MEK1, induces apoptosis in leukemia cells NB4 and MOLT-4. Leuxinostat inhibits the expansion of hematopoietic stem cells and exhibits antileukemic activity in zebrafish models[1].
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Molecular Formula
C18H20N4O4
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Molecular Weight
356.38
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Smiles
O=C(NO)C(C=C1)=CC=C1CN2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2
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Target
Apoptosis; HDAC
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Isoform
HDAC1; HDAC10; HDAC11; HDAC3; HDAC6; HDAC8
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Shipping Conditions
Room temperature
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Leuxinostat
Leuxinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.