Liarozole (dihydrochloride) [CAS 1883548-96-6]
Liarozole (dihydrochloride) [CAS 1883548-96-6]
SKU:QM-0112047-01
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Product Details
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Description
Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA) . Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26) -dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties[1][2][3].
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CAS Number
[1883548-96-6]
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Molecular Formula
C17H15Cl3N4
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Molecular Weight
381.69
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Smiles
ClC1=CC(C(C2=CC=C3N=CNC3=C2)N4C=CN=C4)=CC=C1.[H]Cl.[H]Cl
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Target
Cytochrome P450; RAR/RXR
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Isoform
CYP26
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Purity
99.04
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Liarozole (dihydrochloride) [CAS 1883548-96-6]
Liarozole (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.