Linifanib (Standard) [CAS 796967-16-3]
Linifanib (Standard) [CAS 796967-16-3]
SKU:QM-0017439
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Product Details
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Description
Linifanib (Standard) is the analytical standard of Linifanib. This product is intended for research and analytical applications. Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis[1][2].
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CAS Number
[796967-16-3]
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Molecular Formula
C21H18FN5O
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Molecular Weight
375.4
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Smiles
O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
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Target
Apoptosis; Autophagy; c-Fms; c-Kit; FLT3; PDGFR; Reference Standards; VEGFR
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Shipping Conditions
Room temperature
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Linifanib (Standard) [CAS 796967-16-3]
Linifanib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.