Losartan Carboxylic Acid (Standard) [CAS 124750-92-1]
Losartan Carboxylic Acid (Standard) [CAS 124750-92-1]
SKU:QM-0078347-01
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Product Details
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Description
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC) . Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
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CAS Number
[124750-92-1]
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Molecular Formula
C22H21ClN6O2
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Molecular Weight
436.89
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Smiles
O=C(C1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O
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Target
Angiotensin Receptor; Drug Metabolite; Reference Standards
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Shipping Conditions
Room temperature
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Hazard Statement
H317-H360-H362
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Precautions
P260-P261-P263-P264-P270-P272-P280-P302+P352-P362+P364-P405-P501
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Losartan Carboxylic Acid (Standard) [CAS 124750-92-1]
Losartan Carboxylic Acid (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.