LSD1/HDAC-IN-3
LSD1/HDAC-IN-3
SKU:QM-0013338
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Product Details
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Description
LSD1/HDAC-IN-3 is a inhibitor targeting class I HDAC and LSD1 enzymes. LSD1/HDAC-IN-3 inhibits HDAC1, HDAC2, HDAC3, and LSD1 with IC50 values of 1702 nM, 842 nM, 358 nM, and 1074 nM, respectively. LSD1/HDAC-IN-3 exhibits antioxidant effects in H2O2-stressed ARPE-19 and 661W retinal cells, increasing levels of acetylated and methylated histone H3. LSD1/HDAC-IN-3 enhances photoreceptor survival in the rd10 mouse model of retinitis pigmentosa. LSD1/HDAC-IN-3 can be used for the study of inherited retinal diseases such as retinitis pigmentosa (RP) [1].
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Molecular Formula
C28H32N4O
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Molecular Weight
440.58
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Smiles
O=C(NC1=CC=CC=C1N)C(C=C2)=CC=C2CN(CC3)CCC3N[C@H](C4)[C@@H]4C5=CC=CC=C5
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Target
HDAC; Histone Demethylase
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Isoform
HDAC1; HDAC2; HDAC3
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Shipping Conditions
Room temperature
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LSD1/HDAC-IN-3
LSD1/HDAC-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.