LY2886721 (hydrochloride) [CAS 1262036-49-6]
LY2886721 (hydrochloride) [CAS 1262036-49-6]
SKU:QM-0061947
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Product Details
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Description
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].
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CAS Number
[1262036-49-6]
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Molecular Formula
C18H17ClF2N4O2S
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Molecular Weight
426.87
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Smiles
FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O.[H]Cl
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Target
Beta-secretase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P280-P302+P352
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LY2886721 (hydrochloride) [CAS 1262036-49-6]
LY2886721 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.