Manzamine A [CAS 104196-68-1]
Manzamine A [CAS 104196-68-1]
SKU:QM-0059334
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Product Details
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Description
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].
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CAS Number
[104196-68-1]
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Molecular Formula
C36H44N4O
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Molecular Weight
548.76
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Smiles
O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1
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Target
Autophagy; CDK; GSK-3; HSV; Parasite; Proton Pump
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Isoform
CDK5; GSK-3β; HSV-1; Plasmodium
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Purity
98.2
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Solubility
DMSO : 10 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302
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Precautions
H302
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Manzamine A [CAS 104196-68-1]
Manzamine A is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.