Masitinib (mesylate) [CAS 1048007-93-7]
Masitinib (mesylate) [CAS 1048007-93-7]
SKU:QM-0081833-01
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Product Details
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Description
Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit) . It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity[1][2][4].
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CAS Number
[1048007-93-7]
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Molecular Formula
C29H34N6O4S2
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Molecular Weight
594.75
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Smiles
O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4.CS(=O)(O)=O
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Target
Apoptosis; c-Kit; FGFR; PDGFR; Src
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Purity
99.98
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Solubility
1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 30 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Masitinib (mesylate) [CAS 1048007-93-7]
Masitinib (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.