Masticadienonic acid [CAS 514-49-8]
Masticadienonic acid [CAS 514-49-8]
SKU:QM-0024566
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Product Details
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Description
Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease[1].
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CAS Number
[514-49-8]
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Molecular Formula
C30H46O3
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Molecular Weight
454.68
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Smiles
C[C@@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)[C@@]3([H])CC[C@]1([C@](CC2)([H])[C@@H](C)CC/C=C(C)\C(O)=O)C
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Target
Keap1-Nrf2; NF-κB; p38 MAPK
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Shipping Conditions
Room temperature
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Masticadienonic acid [CAS 514-49-8]
Masticadienonic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.