Metformin-d6 (hydrochloride) [CAS 1185166-01-1]
Metformin-d6 (hydrochloride) [CAS 1185166-01-1]
SKU:QM-0136774-01
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Product Details
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Description
Metformin-d6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo[1].
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CAS Number
[1185166-01-1]
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Molecular Formula
C4H6D6ClN5
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Molecular Weight
171.66
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Smiles
NC(NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)=N.[H]Cl
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Target
AMPK; Apoptosis; Autophagy; Isotope-Labeled Compounds; Mitophagy; mTOR
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Isoform
AMPK
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Purity
99.98
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319
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Precautions
H302, H315, H319
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Metformin-d6 (hydrochloride) [CAS 1185166-01-1]
Metformin-d6 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.