Metformin (hydrochloride) [CAS 1115-70-4]
Metformin (hydrochloride) [CAS 1115-70-4]
SKU:QM-0154607-01
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Product Details
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Description
Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo[1][2][3][4][5][6][7].
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CAS Number
[1115-70-4]
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Molecular Formula
C4H12ClN5
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Molecular Weight
165.62
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Smiles
NC(NC(N(C)C)=N)=N.Cl
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Target
AMPK; Apoptosis; Autophagy; Mitophagy; mTOR
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Isoform
AMPK
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Purity
99.98
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Solubility
DMSO : ≥ 1.7 mg/mL|H2O : ≥ 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Metformin (hydrochloride) [CAS 1115-70-4]
Metformin (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.