Midostaurin-13C6
Midostaurin-13C6
SKU:QM-0054066
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Product Details
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Description
Midostaurin-13C6 (PKC412-13C6) is the 13C-labeled Midostaurin. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects[3].
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Molecular Formula
C29 13C6H30N4O4
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Molecular Weight
576.59
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Smiles
O=C(N([C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5CNC8=O)C=CC=C4)C)[13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9
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Target
Apoptosis; c-Kit; Isotope-Labeled Compounds; NO Synthase; PKC; VEGFR
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Shipping Conditions
Room temperature
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Midostaurin-13C6
Midostaurin-13C6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.