Midostaurin (Standard) [CAS 120685-11-2]
Midostaurin (Standard) [CAS 120685-11-2]
SKU:QM-0081865-01
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Product Details
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Description
Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects[3].
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CAS Number
[120685-11-2]
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Molecular Formula
C35H30N4O4
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Molecular Weight
570.64
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Smiles
O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
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Target
Apoptosis; c-Kit; NO Synthase; PKC; Reference Standards; VEGFR
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Purity
99.78
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Storage Conditions
-20°C, sealed and dry storage, away from light and moisture
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Shipping Conditions
Blue Ice
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Midostaurin (Standard) [CAS 120685-11-2]
Midostaurin (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.