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Migalastat [CAS 108147-54-2]
Migalastat [CAS 108147-54-2]
SKU:QM-0068256
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Product Details
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Description
Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity[1].
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CAS Number
[108147-54-2]
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Molecular Formula
C6H13NO4
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Molecular Weight
163.17
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Smiles
O[C@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
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Target
Glycosidase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H320
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Precautions
P264-P280-P302+P352-P305+P351+P338-P362
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Migalastat [CAS 108147-54-2]
Migalastat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.