Migalastat (hydrochloride) [CAS 75172-81-5]
Migalastat (hydrochloride) [CAS 75172-81-5]
SKU:QM-0150012-01
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Product Details
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Description
Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity[1].
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CAS Number
[75172-81-5]
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Molecular Formula
C6H14ClNO4
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Molecular Weight
199.63
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Smiles
O[C@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.Cl
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Target
Glycosidase
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Purity
99
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Solubility
H2O : ≥ 200 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Migalastat (hydrochloride) [CAS 75172-81-5]
Migalastat (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.