Mitoxantrone-d8 (hydrochloride)
Mitoxantrone-d8 (hydrochloride)
SKU:QM-0006154
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Product Details
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Description
Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride) ) is deuterium labeled Mitoxantrone (dihydrochloride) . Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
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Molecular Formula
C22H21D8ClN4O6
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Molecular Weight
488.99
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Smiles
O=C1C2=C(C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O)C(O)=CC=C2O.Cl
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Target
Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus; PKC; Topoisomerase
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Shipping Conditions
Room temperature
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Mitoxantrone-d8 (hydrochloride)
Mitoxantrone-d8 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.