Monascuspiloin [CAS 1011244-19-1]
Monascuspiloin [CAS 1011244-19-1]
SKU:QM-0108581-01
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Product Details
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Description
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice[1][2].
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CAS Number
[1011244-19-1]
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Molecular Formula
C21H28O5
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Molecular Weight
360.44
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Smiles
C[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@H](C(O1)=O)[C@@H](O)CCCCC
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Target
Akt; AMPK; Androgen Receptor; Apoptosis; Autophagy; mTOR
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Purity
95
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Monascuspiloin [CAS 1011244-19-1]
Monascuspiloin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.