MPP+-d3 (iodide) [CAS 207556-07-8]
MPP+-d3 (iodide) [CAS 207556-07-8]
SKU:QM-0196775-01
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Product Details
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Description
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide) . MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) [1][2].
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CAS Number
[207556-07-8]
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Molecular Formula
C12H9D3IN
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Molecular Weight
300.15
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Smiles
[2H]C([2H])([2H])[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
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Target
Mitochondrial Metabolism
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Purity
99.21
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Solubility
DMSO : 100mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H311, H315, H319, H331, H335
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Precautions
H301, H311, H315, H319, H331, H335
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MPP+-d3 (iodide) [CAS 207556-07-8]
MPP+-d3 (iodide) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.