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MRTX849 ethoxypropanoic acid [CAS 2561529-98-2]
MRTX849 ethoxypropanoic acid [CAS 2561529-98-2]
SKU:QM-0063692
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Product Details
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Description
MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2. LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM)[2].
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CAS Number
[2561529-98-2]
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Molecular Formula
C37H43ClFN7O5
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Molecular Weight
720.23
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Smiles
O=C(N1CCN(C2=C3CCN(CC3=NC(OC[C@@H]4CCCN4CCCOCCC(O)=O)=N2)C5=CC=CC6=C5C(Cl)=CC=C6)C[C@@H]1CC#N)C(F)=C
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Target
Ras; Target Protein Ligand-Linker Conjugates
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Isoform
K-Ras
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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MRTX849 ethoxypropanoic acid [CAS 2561529-98-2]
MRTX849 ethoxypropanoic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.