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N-Ac-γ-Calicheamicin-AcBut-NHS ester [CAS 174885-02-0]

N-Ac-γ-Calicheamicin-AcBut-NHS ester [CAS 174885-02-0]

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SKU:QM-0083473

£9,087.17 GBP
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  • Description

    AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies[1].

  • CAS Number

    [174885-02-0]

  • Molecular Formula

    C77H99IN6O28S3

  • Molecular Weight

    1779.73

  • Smiles

    O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSC(C)(C)CC(N/N=C(C8=CC=C(OCCCC(ON(C9=O)C(CC9)=O)=O)C=C8)\C)=O

  • Target

    ADC Payload

  • Purity

    95.62

  • Storage Conditions

    -20°C (Powder, sealed storage, away from moisture and light)

  • Shipping Conditions

    Blue Ice

  • Hazard Statement

    H300, H310, H315, H319, H330, H335, H351

  • Precautions

    H300, H310, H315, H319, H330, H335, H351

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1 mgQM-0083473
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N-Ac-γ-Calicheamicin-AcBut-NHS ester [CAS 174885-02-0]

N-Ac-γ-Calicheamicin-AcBut-NHS ester is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.