N-alpha-Tosyl-Lys chloromethyl ketone (hydrochloride) [CAS 4238-41-9]
N-alpha-Tosyl-Lys chloromethyl ketone (hydrochloride) [CAS 4238-41-9]
SKU:QM-0145821
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Product Details
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Description
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 μM, respectively. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis[1].
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CAS Number
[4238-41-9]
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Molecular Formula
C14H22Cl2N2O3S
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Molecular Weight
369.31
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Smiles
O=S(C1=CC=C(C)C=C1)(NC(C(CCl)=O)CCCCN)=O.Cl
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Target
Caspase; Ser/Thr Protease
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Isoform
Caspase 3; Caspase 6; Caspase 7
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H335
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Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
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N-alpha-Tosyl-Lys chloromethyl ketone (hydrochloride) [CAS 4238-41-9]
N-alpha-Tosyl-Lys chloromethyl ketone (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.