N-Desmethylclozapine-d8 (hydrochloride) [CAS 2705402-91-9]
N-Desmethylclozapine-d8 (hydrochloride) [CAS 2705402-91-9]
SKU:QM-0161546-01
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Product Details
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Description
N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
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CAS Number
[2705402-91-9]
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Molecular Formula
C17H10D8Cl2N4
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Molecular Weight
357.31
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Smiles
ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1.[H]Cl
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Target
Drug Metabolite; mAChR; Opioid Receptor; Virus Protease
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Purity
99.74
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Solubility
10 mM in DMSO|DMSO : ≥ 50mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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N-Desmethylclozapine-d8 (hydrochloride) [CAS 2705402-91-9]
N-Desmethylclozapine-d8 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.