N-Desmethyltamoxifen (hydrochloride) [CAS 15917-65-4]
N-Desmethyltamoxifen (hydrochloride) [CAS 15917-65-4]
SKU:QM-0142772-01
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Product Details
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Description
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
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CAS Number
[15917-65-4]
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Molecular Formula
C25H28ClNO
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Molecular Weight
393.95
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Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3.[H]Cl
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Target
Drug Metabolite; Endogenous Metabolite; Estrogen Receptor/ERR; PKC
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Isoform
PKC
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Purity
99.63
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Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H350, H360, H400, H410
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Precautions
H350, H360, H400, H410
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N-Desmethyltamoxifen (hydrochloride) [CAS 15917-65-4]
N-Desmethyltamoxifen (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.