N-piperidine Ibrutinib (hydrochloride) [CAS 2231747-18-3]
N-piperidine Ibrutinib (hydrochloride) [CAS 2231747-18-3]
SKU:QM-0143470-01
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Product Details
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Description
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2].
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CAS Number
[2231747-18-3]
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Molecular Formula
C22H23ClN6O
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Molecular Weight
422.91
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Smiles
NC1=C2C(N(C3CCNCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1.[H]Cl
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Target
Btk; Ligands for Target Protein for PROTAC
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Purity
98.06
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319
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Precautions
H302, H315, H319
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N-piperidine Ibrutinib (hydrochloride) [CAS 2231747-18-3]
N-piperidine Ibrutinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.