N1-Acetyl-5-methoxykynuramine (hydrochloride) [CAS 1215711-91-3]
N1-Acetyl-5-methoxykynuramine (hydrochloride) [CAS 1215711-91-3]
SKU:QM-0052292-01
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Product Details
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Description
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin. N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases[1][2][3][4][5][6]
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CAS Number
[1215711-91-3]
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Molecular Formula
C12H17ClN2O3
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Molecular Weight
272.73
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Smiles
O=C(C)NCCC(C1=CC(OC)=CC=C1N)=O.Cl
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Target
COX; PGE synthase; Prostaglandin Receptor; Reactive Oxygen Species (ROS)
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Isoform
COX-2
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H361
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Precautions
P264-P270-P280-P330-P405-P501
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N1-Acetyl-5-methoxykynuramine (hydrochloride) [CAS 1215711-91-3]
N1-Acetyl-5-methoxykynuramine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.