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Naldemedine (tosylate) [CAS 1345728-04-2]

Naldemedine (tosylate) [CAS 1345728-04-2]

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SKU:QM-0155424-01

£379.26 GBP
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  • Description

    Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA) [1]. Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors[2]. Naldemedine can be used in opioid-induced constipation (OIC) research[2]. Naldemedine tosylate is predicted to bind to 3CLpro encoded by SARS-CoV2 genome[3].

  • CAS Number

    [1345728-04-2]

  • Molecular Formula

    C39H42N4O9S

  • Molecular Weight

    742.84

  • Smiles

    O[C@@]1(CC(C(NC(C)(C2=NC(C3=CC=CC=C3)=NO2)C)=O)=C4O)[C@@]([C@@]4([H])OC5=C6O)(CC7)C5=C(C=C6)C[C@@]1([H])N7CC8CC8.CC9=CC=C(S(=O)(O)=O)C=C9

  • Target

    Opioid Receptor

  • Isoform

    μ Opioid Receptor/MOR

  • Purity

    92.16

  • Solubility

    DMSO : 50 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C (Powder, stored under nitrogen, away from moisture)

  • Shipping Conditions

    Blue Ice

  • Hazard Statement

    H302, H312, H332

  • Precautions

    H302, H312, H332

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Variant Variant total Quantity Price Variant total
1 mgQM-0155424-01
1 mgQM-0155424-01
£379.26/ea
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£379.26/ea £0.00
5 mgQM-0155424-02
5 mgQM-0155424-02
£629.55/ea
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£629.55/ea £0.00
10 mgQM-0155424-03
10 mgQM-0155424-03
£978.26/ea
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£978.26/ea £0.00
25 mgQM-0155424-04
25 mgQM-0155424-04
£1,582.12/ea
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£1,582.12/ea £0.00
50 mgQM-0155424-05
50 mgQM-0155424-05
£2,196.91/ea
£0.00
£2,196.91/ea £0.00
100 mgQM-0155424-06
100 mgQM-0155424-06
£3,054.70/ea
£0.00
£3,054.70/ea £0.00

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Naldemedine (tosylate) [CAS 1345728-04-2]

Naldemedine (tosylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.