Nanatinostat [CAS 1256448-47-1]
Nanatinostat [CAS 1256448-47-1]
SKU:QM-0144695-01
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Product Details
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Description
Nanatinostat (CHR-3996) is a potent, class I selective and orally active HDAC inhibitor with IC50s of 3 nM, 4 nM, and 7 nM for HDAC1, HDAC2, and HDAC3, respectively. Nanatinostat has low activity against HDAC5 (IC50 of 200 nM) and HDAC6 (IC50 of 2100 nM) . Nanatinostat induces apoptosis in myeloma cells. Nanatinostat has potent anticancer effects, such as myeloma, advanced solid tumours and colorectal cancer[1][2][3].
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CAS Number
[1256448-47-1]
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Molecular Formula
C20H19FN6O2
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Molecular Weight
394.4
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Smiles
FC(C=C1)=CC(C=C2)=C1N=C2CN[C@H]3[C@@]4([H])[C@]3([H])CN(C5=NC=C(C(NO)=O)C=N5)C4
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Target
Apoptosis; HDAC
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Isoform
HDAC; HDAC1; HDAC2; HDAC3; HDAC5; HDAC6
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Purity
99.67
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Nanatinostat [CAS 1256448-47-1]
Nanatinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.