Necrostatin 2 (S enantiomer) [CAS 852391-20-9]
Necrostatin 2 (S enantiomer) [CAS 852391-20-9]
SKU:QM-0148884-01
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Product Details
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Description
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2. Necrostatin 2 is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect. Target: RIPK1 [4] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5- (1H-Indol-3-ylmethyl) -2-thiohydantoins and 5- (1H-indol-3-ylmethyl) hydantoins were found to be potent necroptosis inhibitors (called necrostatins) .
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CAS Number
[852391-20-9]
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Molecular Formula
C13H12ClN3O2
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Molecular Weight
277.71
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Smiles
O=C1N(C)C([C@H](CC2=CNC3=C2C=CC=C3Cl)N1)=O
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Target
RIP kinase
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Isoform
RIPK1
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Purity
99.65
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Necrostatin 2 (S enantiomer) [CAS 852391-20-9]
Necrostatin 2 (S enantiomer) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.