Nepafenac-d5 [CAS 1246814-53-8]
Nepafenac-d5 [CAS 1246814-53-8]
SKU:QM-0154425-01
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Product Details
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Description
Nepafenac-d5 (AHR-9434-d5; AL-6515-d5) is the deuterium labeled Nepafenac. Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.
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CAS Number
[1246814-53-8]
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Molecular Formula
C15H9D5N2O2
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Molecular Weight
259.31
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Smiles
O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=CC=CC(CC(N)=O)=C2N
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Target
COX; Endogenous Metabolite; Isotope-Labeled Compounds; Prostaglandin Receptor
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Purity
98.84
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Nepafenac-d5 [CAS 1246814-53-8]
Nepafenac-d5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.