Nepafenac (Standard) [CAS 78281-72-8]
Nepafenac (Standard) [CAS 78281-72-8]
SKU:QM-0094123-01
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Product Details
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Description
Nepafenac (AHR 9434; AL 6515) (Standard) is the analytical standard of Nepafenac. This product is intended for research and analytical applications. Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.
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CAS Number
[78281-72-8]
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Molecular Formula
C15H14N2O2
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Molecular Weight
254.28
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Smiles
O=C(N)CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N
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Target
COX; Endogenous Metabolite; Prostaglandin Receptor; Reference Standards
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Shipping Conditions
Room temperature
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Nepafenac (Standard) [CAS 78281-72-8]
Nepafenac (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.