Netarsudil (hydrochloride) [CAS 1253952-02-1]
Netarsudil (hydrochloride) [CAS 1253952-02-1]
SKU:QM-0142265-01
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Product Details
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Description
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET) . Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma[1][2][3][4].
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CAS Number
[1253952-02-1]
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Molecular Formula
C28H29Cl2N3O3
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Molecular Weight
526.45
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Smiles
CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1.[H]Cl.[H]Cl
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Target
ROCK
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Purity
99.9
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Solubility
DMSO : 5 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Netarsudil (hydrochloride) [CAS 1253952-02-1]
Netarsudil (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.