Niraparib (tosylate hydrate) [CAS 1613220-15-7]
Niraparib (tosylate hydrate) [CAS 1613220-15-7]
SKU:QM-0112101-01
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Product Details
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Description
Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].
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CAS Number
[1613220-15-7]
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Molecular Formula
C26H30N4O5S
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Molecular Weight
510.61
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Smiles
NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O
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Target
Apoptosis; PARP
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Isoform
PARP1; PARP2; PARP3; PARP4; TNKS1/PARP5A
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Purity
99.97
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Niraparib (tosylate hydrate) [CAS 1613220-15-7]
Niraparib (tosylate hydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.